Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (2): 105-107.doi: 10.3969/j.issn.1004-616x.2000.02.014

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STUDY ON THE ANTIMUTAGENICITY OF LENTINAN

CHEN Guan-min , LIN Sheng-qing , HUANG Zong-xiu , CHEN Ren-xiong , HE Ling , JIANG Rui-chai   

  1. Fujian Provincial Health and Anti-epiodemic Station , Fuz hou  350001 , China
  • Received:1999-06-16 Revised:1999-09-29 Online:2000-04-30 Published:2000-04-30

Abstract: Purpose and Methods : The effect on antimutation of Lentinan was studied by Ames test and micronucleus test with polychromatic erythrocyte (PCE) of mouse bone marrow in vivo. Results : The rusult s show that the increasing of the number of bacteria in different dose groups can be inhibited by Lentinan. Lentinan inhibited the increasing of micronucleus rate and the inhibition rate is between 45. 32 % and 64. 72 %. Conclusion : It has been observed that Lentinan possess significant antimutagenic effect .

Key words: Lentinan, antimutagenicity, Ames test, micronucleus test

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